| ncRNA name | hsa-miR-449b |
| ncRNA Category | miRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RB samples, normal retinas; human RB cell lines Y79 and Weri1 |
| Methods | qPCR, transfection |
| Expression pattern | up-regulated |
| Functional description | Despite a predicted role as a tumor suppressor that functions to augment both Rb-mediated control over cell proliferation and p53 mediated apoptosis, both miR-449a and -449b were overexpressed in our tumor cohort. A potential explanation for this may be that the inhibitory effects on proliferation are only seen at higher levels achieved by transfection. |
| PubMed ID | 24120948 |
| Year | 2013 |
| Title | MicroRNAs-449a and -449b exhibit tumor suppressive effects in retinoblastoma. |
| Drug-related ncRNA | NO |
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